Singapore researchers develop rapid gut biomarker nanosensor

The optical platform can detect indole-3-propionic acid within minutes.

Researchers in Singapore have developed a fluorescent nanosensor to detect indole-3-propionic acid (IPA), a metabolite produced by the gut microbiome.

The platform was developed through a collaboration involving NIE NTU, the Singapore-MIT Alliance for Research and Technology, National University Hospital, and the National University of Singapore.

It is reported to be the first optical nanosensor specifically engineered to detect IPA, which is being studied as a potential biomarker linked to inflammation, metabolic disorders, and chronic diseases.

Unlike conventional mass spectrometry-based methods, which require specialised laboratory equipment and longer processing times, the nanosensor can generate optical readings within minutes.

GlobalData said the technology could improve the accessibility and efficiency of biomarker testing in research and, subject to clinical validation, support future monitoring applications.

The platform may also help pharmaceutical researchers study microbiome-related interventions, probiotics, and new treatment strategies.

GlobalData added that the innovation could help bridge laboratory-based biomarker analysis with future preventive and personalised healthcare applications.

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